Altered resting functional connectivity patterns associated with problematic substance use and substance use disorders during adolescence

D Rakesh; J Lv; A Zalesky; NB Allen; DI Lubman; M Yücel; S Whittle

Journal article

Altered resting functional connectivity patterns associated with problematic substance use and substance use disorders during adolescence

D Rakesh, J Lv, A Zalesky, NB Allen, DI Lubman, M Yücel, S Whittle

Journal of Affective Disorders | ELSEVIER | Published : 2021

DOI: 10.1016/j.jad.2020.10.051

Abstract

Background: Adolescence is typified by increasing rates of substance use and the development of substance use disorders (SUD). Aberrant connectivity between cortical regions involved in executive control, and subcortical regions has been suggested to be associated with SUD and problematic substance use among adolescents. Few studies, however, have investigated system-level or whole-brain functional connectivity (FC) in order to test this hypothesis. Methods: In a sample of 114 adolescents (mean age = 17.62 years, SD = 1.23, 61F) from the community, the present study used resting-state functional magnetic resonance imaging and independent component analysis to study executive control-subcorti..

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University of Melbourne Researchers

Andrew Zalesky Author

Nick Allen Author

Sarah Whittle Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This study was funded by the Colonial Foundation, the National Health and Medical Research Council (NHMRC; Australia; Program Grant 350241), and the Australian Research Council (ARC; Discovery Grants DP0878136 and DP109 2637). DR was supported by a Melbourne Research Scholarship (MRS; University of Melbourne). JL was supported by an NHMRC Project Grant (ID: 071242). AZ was supported by an NHMRC Senior Research Fellowship (ID: 1136649). MY was supported by a fellowship from the NHMRC (ID. 1117188) and the David Winston Turner Endowment Fund. SW was supported by an NHMRC Career Development Fellowship (ID: 1125504).